Clinical Trials & Surveys
“Those of us with adrenal disease know the importance of having new treatments that will give us an opportunity to have the best quality of life with improved medical options. Participation in clinical trials can help accelerate the development of new treatments and address our community’s unmet medical needs.”
All clinical trials listed below are for informational purposes only. NADF does not endorse these or any products.
MyAI Registry: Enrolling Participants for Online, Patient-Centered, Adrenal Insufficiency Study
If you have adrenal insufficiency – we want you!
We are looking to continue recruiting people for a large cohort study of adrenal insufficiency – with a focus on symptoms, diagnosis, quality of life, and outcomes of treatment.
Help Us Improve Online Information About Adrenal Nodules
Have you ever searched online for medical information and wondered if you could trust what you found?
We are studying how artificial intelligence (AI) tools answer common questions about adrenal nodules. We asked five popular AI programs to respond to questions patients often ask. Now, we would like your help reviewing those responses.
You do not need any medical background to participate — we are specifically looking for feedback from patients, family members, and members of the general public.
In this short survey (about 15 minutes), you will:
Read AI-generated answers to common questions about adrenal nodules
Share your thoughts on whether the information is clear and helpful
Help us improve the quality of medical information available to patients online
Your perspective matters! By participating, you will help us better understand how patients interpret AI-generated health information and how it can be improved.
New Study: “Biomarker-Based Strategies for Optimizing Adrenal Insufficiency Management”
Sponsor: Mayo Clinic
Contact: Vanessa Fell fell.vanessa@mayo.edu
Enrolling adults diagnosed with classic CAH. The study uses an Oura Ring to better understand how sleep, activity, heart rate, temperature, glucocorticoid therapy, and medical events relate to day-to-day health in patients experiencing adrenal insufficiency.
RESET-MACS Study: A New Treatment Approach for Mild Autonomous Cortisol Secretion (MACS)
Sponsor: Mayo Clinic
Contact: Vanessa Fell fell.vanessa@mayo.edu
Adults age 18 years and older with diagnosed with Mild Autonomous Cortisol Secretion (MACS) may be eligible for a Mayo Clinic research study evaluating an investigational study drug, Metyrapone. The study lasts about 7 months, with an optional 6-month extension, and includes inpatient visits at Mayo Clinic in Rochester, Minnesota. Participants will be compensated for their time.
Pharmacokinetic (PK), Pharmacodynamic (PD), and Tolerability of Osilodrostat in Pediatric Patients with Cushing’s Syndrome
Is your child suffering from Cushing’s syndrome? You may consider their participation in LINC-5 study which evaluates the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with Cushing's syndrome.
Sponsor: Recordati Rare Diseases
Who should consider participating: Children and adolescents 2 to <18 years of age with Cushing’s syndrome may qualify to participate in the LINC-5 study
To learn more, please reach out to your nearest research site:
Dr. Maya Lodish
University of California San Francisco
San Franciso, CA
luis.gay@ucsf.eduDr. Wendy Brickman
Ann & Robert H. Lurie Children's Hospital
Chicago, IL
emarshall@luriechildrens.orgDr. Paige Vanier Kreegel
ABMED Clinical Research Corp
Cape Coral, FL
dacosta@abmedclinicalresearch.comDr. Eduardo Dusty Luna
Texas Valley Clinical Research
Weslaco, TX
hale.rn@tvcrtrials.com
Evaluating the Functional Status of the Adrenal Glands Hyperaldosteronism
Objective of this study is to see if a new radioactive tracer ([68Ga]Ga-PentixaFor) can make it easier to identify functional adrenal tumors leading to hyperaldosteronism.
Sponsor: National Cancer Institute
Principal Investigator:
Maria Liza Lindenberg, M.D.
Phone Number: (240) 760-6109
Email: liza.lindenberg@mail.nih.gov
Who should consider participation: People aged 18 years and older with 1 or more adrenal tumors. They must have increased levels of the hormone aldosterone.
Updated Diagnostic Cortisol Values for Adrenal Insufficiency
The purpose of this study is to determine the cortisol levels that most accurately diagnose a patient with adrenal insufficiency, a condition in which cortisol levels are too low for daily living.
Sponsor: Montefiore Medical Center
Contact: Smita B. Abraham, MD; email: smabraham@montefiore.org
Who should consider participating: If you are a male or a female, 18 years or older, consider participation to help determine the appropriate level of cortisol in healthy individuals to allow a more accurate diagnosis of people with adrenal insufficiency.