FOR INFORMATION ON COVID-19, GO TO COVID-19 INFORMATION HERE.
CORTISONE ACETATE SHORTAGE
December 30, 2020
West-Ward Pharmaceuticals stated that 25 mg cortisone acetate tablets are on a backorder currently due to production delays. The ETA for distributors to receive inventory is the week of January 4th and to allow a few days for availability.
See the Corticosteroid Comparison Chart here
West-Ward Pharmaceuticals stated that 25 mg cortisone acetate tablets are on a backorder currently due to production delays. The ETA for distributors to receive inventory is the week of January 4th and to allow a few days for availability.
See the Corticosteroid Comparison Chart here
statement from NADF's medical advisor about the covid-19 vaccine
December 17, 2020
Many are questioning whether the COVID-19 vaccine is safe for those with adrenal insufficiency. After a review, NADF’s Medical Advisor Dr. Margulies provided this statement:
“At this time, I am satisfied that the FDA has done the appropriate review of the Pfizer vaccine, and I am enthusiastic about recommending it to every adult. I plan to take it myself. There is no reason for anyone with adrenal insufficiency, whether primary or secondary, to avoid this vaccine. It is as safe as the influenza vaccine. It has mild side effects, such as sore arm, mild fever and fatigue that last about one day. The Moderna vaccine will be reviewed soon, but so far it looks very similar to the Pfizer product. Unless something surprising is found, I expect it will also be suitable for every adult.”
Additional information:
As always, you and your doctor should decide together if the vaccine is right for you and, if so, which one.
Many are questioning whether the COVID-19 vaccine is safe for those with adrenal insufficiency. After a review, NADF’s Medical Advisor Dr. Margulies provided this statement:
“At this time, I am satisfied that the FDA has done the appropriate review of the Pfizer vaccine, and I am enthusiastic about recommending it to every adult. I plan to take it myself. There is no reason for anyone with adrenal insufficiency, whether primary or secondary, to avoid this vaccine. It is as safe as the influenza vaccine. It has mild side effects, such as sore arm, mild fever and fatigue that last about one day. The Moderna vaccine will be reviewed soon, but so far it looks very similar to the Pfizer product. Unless something surprising is found, I expect it will also be suitable for every adult.”
Additional information:
- Many people in the clinical trials had some short-term side effects from taking the COVID-19 vaccine. The side effects are usually not serious -- one of the most common is a sore or achy arm. Some people develop low-grade fevers or chills and feel tired. This is because the vaccine is working and causing a response from the immune system. As always, follow NADF’s stress dosing guidelines to determine if you need additional steroids.
- Remember that the Pfizer vaccine is given in two doses three weeks apart. It is more common to have side effects from the second dose than the first. You must receive both doses to get the full benefit from the vaccine.
- The vaccine may not be available to most people until spring or summer of 2021. Because of the limited supply of the vaccines, people at very high risk, such as health care providers and people who live in nursing homes or assisted living facilities, will get a vaccine before people whose risk of illness is lower.
As always, you and your doctor should decide together if the vaccine is right for you and, if so, which one.
Eton Pharmaceuticals Announces Availability of Orphan Drug ALKINDI® SPRINKLE (hydrocortisone) in the United States
November 24, 2020
DEER PARK, Ill., (GLOBE NEWSWIRE): Eton Pharmaceuticals, Inc. (Nasdaq: ETON), a specialty pharmaceutical company focused on developing and commercializing innovative treatments for rare pediatric diseases, today announced the full availability of ALKINDI® SPRINKLE for sale and distribution in the United States.
SEE FULL ANNOUNCEMENT: https://ir.etonpharma.com/news-releases/news-release-details/eton-pharmaceuticals-announces-availability-orphan-drug-alkindir
DEER PARK, Ill., (GLOBE NEWSWIRE): Eton Pharmaceuticals, Inc. (Nasdaq: ETON), a specialty pharmaceutical company focused on developing and commercializing innovative treatments for rare pediatric diseases, today announced the full availability of ALKINDI® SPRINKLE for sale and distribution in the United States.
SEE FULL ANNOUNCEMENT: https://ir.etonpharma.com/news-releases/news-release-details/eton-pharmaceuticals-announces-availability-orphan-drug-alkindir
eton pharmaceuticals announces fda approval of orphan drug alkindi® sprinkle (hYDROCORTISONE) AS REPLACEMENT THERAPY IN PEDIATRIC PATIENTS WITH ADRENOCORTICAL INSUFFICIENCY
September 29, 2020
ALKINDI SPRINKLE is the first and only FDA-approved granular hydrocortisone formulation for adrenocortical insufficiency specifically designed for children. Eton expects ALKINDI SPRINKLE to be available in the fourth quarter of 2020.
SEE ARTICLE: https://www.globenewswire.com/news-release/2020/09/29/2101010/0/en/Eton-Pharmaceuticals-Announces-FDA-Approval-of-Orphan-Drug-ALKINDI-SPRINKLE-hydrocortisone-as-Replacement-Therapy-in-Pediatric-Patients-with-Adrenocortical-Insufficiency.html
ALKINDI SPRINKLE is the first and only FDA-approved granular hydrocortisone formulation for adrenocortical insufficiency specifically designed for children. Eton expects ALKINDI SPRINKLE to be available in the fourth quarter of 2020.
SEE ARTICLE: https://www.globenewswire.com/news-release/2020/09/29/2101010/0/en/Eton-Pharmaceuticals-Announces-FDA-Approval-of-Orphan-Drug-ALKINDI-SPRINKLE-hydrocortisone-as-Replacement-Therapy-in-Pediatric-Patients-with-Adrenocortical-Insufficiency.html
Acella Pharmaceuticals, LLC Issues Voluntary Nationwide Recall of Two Lots of NP Thyroid®, Thyroid Tablets, USP Due to Sub Potency
September 22, 2020
Acella Pharmaceuticals, LLC is voluntarily recalling one lot of 15-mg and one lot of 120-mg NP Thyroid®, Thyroid Tablets, USP [levothyroxine (T4) and liothyronine (T3)] to the consumer level. The products are being recalled because testing has found these lots to be sub potent. The product may have as low as 87% of the labeled amount of levothyroxine (T4). More information can be found at www.npthyroid.com/product-updates.
SEE ARTICLE: https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/acella-pharmaceuticals-llc-issues-voluntary-nationwide-recall-two-lots-np-thyroidr-thyroid-tablets?utm_medium=email&utm_source=govdelivery#recall-announcement
Acella Pharmaceuticals, LLC is voluntarily recalling one lot of 15-mg and one lot of 120-mg NP Thyroid®, Thyroid Tablets, USP [levothyroxine (T4) and liothyronine (T3)] to the consumer level. The products are being recalled because testing has found these lots to be sub potent. The product may have as low as 87% of the labeled amount of levothyroxine (T4). More information can be found at www.npthyroid.com/product-updates.
SEE ARTICLE: https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/acella-pharmaceuticals-llc-issues-voluntary-nationwide-recall-two-lots-np-thyroidr-thyroid-tablets?utm_medium=email&utm_source=govdelivery#recall-announcement
adrenal insufficiency fund opens at the healthwell foundation
Copayment and Premium Assistance Now Available
September 14, 2020
GERMANTOWN, MD — The HealthWell Foundation®, an independent non-profit that provides a financial lifeline for inadequately insured Americans, has launched a new fund to provide copayment and premium assistance to patients living with adrenal insufficiency (AI).
GERMANTOWN, MD — The HealthWell Foundation®, an independent non-profit that provides a financial lifeline for inadequately insured Americans, has launched a new fund to provide copayment and premium assistance to patients living with adrenal insufficiency (AI).
PREVENTION OF ADRENAL CRISIS: CORTISOL RESPONSES TO MAJOR STRESS COMPARED TO STRESS DOSE HYDROCORTISONE DELIVERY
July 2020
A recent paper published by The Journal of Clinical Endocrinology & Metabolism* provided updated information on the most appropriate mode of hydrocortisone delivery in patients with adrenal insufficiency that are hospitalized with major surgery or major stress from severe infection. That paper can be found on our website here. https://www.nadf.us/medical-publications.html
The conclusion they came to is that continuous intravenous hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress. This keeps the circulating cortisol in target range over the period of time needed to treat an adrenal crisis.
*The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 7, July 2020, Pages 2262–2274, https://doi.org/10.1210/clinem/dgaa133
A recent paper published by The Journal of Clinical Endocrinology & Metabolism* provided updated information on the most appropriate mode of hydrocortisone delivery in patients with adrenal insufficiency that are hospitalized with major surgery or major stress from severe infection. That paper can be found on our website here. https://www.nadf.us/medical-publications.html
The conclusion they came to is that continuous intravenous hydrocortisone infusion should be favored over intermittent bolus administration in the prevention and treatment of adrenal crisis during major stress. This keeps the circulating cortisol in target range over the period of time needed to treat an adrenal crisis.
*The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 7, July 2020, Pages 2262–2274, https://doi.org/10.1210/clinem/dgaa133
cAH Clinical Program - Spruce biosciences
Spruce Biosciences, a late-stage clinical development company focused on developing and commercializing novel therapies for rare endocrine disorders, has announced the launch of CAHstudy.com a new website and patient resource to enable adults with Congenital Adrenal Hyperplasia (CAH) to register their interest in the CAHmelia clinical program, which is expected to commence in the second half of 2020.
exciting news from nadf
April 25, 2020
We would like to take this opportunity to make some exciting and important announcements. We have seen rapid growth of our foundation over the past decade or so, with the trajectory of growth in the responsibilities required to run NADF accelerating equally as quickly.
We would like to take this opportunity to make some exciting and important announcements. We have seen rapid growth of our foundation over the past decade or so, with the trajectory of growth in the responsibilities required to run NADF accelerating equally as quickly.
For those with adrenal insufficiency and confirmed or suspected Covid-19, increase the dose of hydrocortisone to 20 mg every 6 hours until the fever subsides, and then go back to the usual double dose until completely better.
