MEDICAL PUBLICATIONS
PHASE 3 TRIAL OF CRINECERFONT IN ADULT AND PEDIATRIC CONGENITAL ADRENAL HYPERPLASIA
Two papers on phase 3 trials of a new drug for adult and pediatric CAH that reduces the need for high doses of hydrocortisone. See Adult CAH paper. See Pediatric CAH paper.
GUIDELINE ON GLUCOCORTICOID-INDUCED ADRENAL INSUFFICIENCY
May 13, 2024 Endocrine Society and European Society of Endocrinology publish joint guideline on glucocorticoid-induced adrenal insufficiency. Published in May in the Journal of Clinical Endocrinology and Metabolism, the European Journal Endocrinology, and the ESE Patient Zone. See paper here.
CONSENSUS STATEMENT ON THE DIAGNOSIS, TREATMENT AND FOLLOW-UP OF PATIENTS WITH PRIMARY ADRENAL INSUFFICIENCY
2013 The Association for the Publication of the Journal of Internal Medicine: See paper here.
EPIDEMIOLOGY, PATHOGENESIS, AND DIAGNOSIS OF ADDISON'S DISEASE IN ADULTS
From the Journal of Endocrinological Investigation, Published online: 18 July 2019. See paper here.
RECOGNITION OF NONNEOPLASTIC HYPERCORTISOLISM IN THE EVALUATION OF PATIENTS WITH CUSHING'S SYNDROME
From the Journal of the Endocrine Society, 2023. See paper here.
CURE OF CUSHING'S DISEASE: STILL AN ELUSIVE GOAL?
From The Journal of Clinical Endocrinology & Metabolism, January 2021. See paper here.
OSOLIDROSTAT FOR THE TREATMENT OF CUSHING'S DISEASE: GROWING EVIDENCE IN THE TREATMENT OF RARE ENDOCRINE DISEASES
From The Journal of Clinical Endocrinology & Metabolism, May 2022. See paper here.
STEM CELL FUNCTION AND PLASTICITY IN THE NORMAL PHYSIOLOGY OF THE ADRENAL CORTEX
PUBLISHED JANUARY 1, 2021, Molecular and Cellular Endocrinology, Volume 519, 1 January 2021, 11043
The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and necessitate a precise steroidogenic response. To meet these diverse needs, the adrenal employs multiple cell populations with stem cell function. Here, we discuss the literature on adrenocortical stem cells using hematopoietic stem cells as a benchmark to examine the functional capacity of particular cell populations, including those located in the capsule and peripheral cortex.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736543/
The adrenal cortex functions to produce steroid hormones necessary for life. To maintain its functional capacity throughout life, the adrenal cortex must be continually replenished and rapidly repaired following injury. Moreover, the adrenal responds to endocrine-mediated organismal needs, which are highly dynamic and necessitate a precise steroidogenic response. To meet these diverse needs, the adrenal employs multiple cell populations with stem cell function. Here, we discuss the literature on adrenocortical stem cells using hematopoietic stem cells as a benchmark to examine the functional capacity of particular cell populations, including those located in the capsule and peripheral cortex.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736543/
THEMATIC ISSUE: ADRENAL DISEASE 2021
PUBLISHED SEPTEMBER, 2021, Endocrine Society Publications, Oxford Academic. This is a special collection of journal articles, published in 2020-2021, focused on adrenal disease.
https://academic.oup.com/endocrinesociety/pages/thematic-issue-adrenal-disease-2021
https://academic.oup.com/endocrinesociety/pages/thematic-issue-adrenal-disease-2021
NEW CUTOFF FOR THE BIOCHEMICAL DIAGNOSIS OF ADRENAL INSUFFICIENCY AFTER ACTH STIMULATION USING SPECIFIC CORTISOL ASSAYS
PUBLISHED FEBRUARY 18, 2021, Journal of the Endocrine Society, bvab022, https://doi.org/10.1210/jendso/bvab022
The normal cortisol response 30 or 60 min after cosyntropin (ACTH[1-24]) is considered ≥18 μg/dL (500 nmol/L). This threshold is based on older serum cortisol assays. Specific monoclonal antibody immunoassays or LC-MS/MS may have lower thresholds for a normal response.
https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvab022/6142947?s=09#.YC52GWsOYxc.
The normal cortisol response 30 or 60 min after cosyntropin (ACTH[1-24]) is considered ≥18 μg/dL (500 nmol/L). This threshold is based on older serum cortisol assays. Specific monoclonal antibody immunoassays or LC-MS/MS may have lower thresholds for a normal response.
https://academic.oup.com/jes/advance-article/doi/10.1210/jendso/bvab022/6142947?s=09#.YC52GWsOYxc.
RESIDUAL CORTICOSTEROID PRODUCTION IN AUTOIMMUNE ADDISON'S DISEASE
PUBLISHED JULY 2020, Journal of Clinical Endocrinology & Metabolism, 105(7):2430–2441, doi:10.1210/clinem/dgaa256
Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison disease (AAD) produce corticosteroids even years after diagnosis.
https://academic.oup.com/jcem/article/105/7/2430/5835888
Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison disease (AAD) produce corticosteroids even years after diagnosis.
https://academic.oup.com/jcem/article/105/7/2430/5835888
NATURAL HISTORY OF ADRENAL STEROIDOGENESIS IN AUTOIMMUNE ADDISON'S DISEASE FOLLOWING DIAGNOSIS AND TREATMENT
PUBLISHED JULY 2020, Journal of Clinical Endocrinology & Metabolism, 105(7):2322–2330, doi:10.1210/clinem/dgaa187
The natural history of adrenal function in autoimmune Addison disease once diagnosed and treated has not been systematically studied, but several case reports of recovery from established adrenal failure suggest it may not be uniform.
https://academic.oup.com/jcem/article/105/7/2322/5821191
The natural history of adrenal function in autoimmune Addison disease once diagnosed and treated has not been systematically studied, but several case reports of recovery from established adrenal failure suggest it may not be uniform.
https://academic.oup.com/jcem/article/105/7/2322/5821191
PREVENTION OF ADRENAL CRISIS: CORTISOL RESPONSES TO MAJOR STRESS COMPARED TO STRESS DOSE HYDROCORTISONE DELIVERY
PUBLISHED JULY 20, 2020, Journal of Clinical Endocrinology &Metabolism, 105(7):2262– 2274, doi:10.1210/clinem/dgaa133
Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery
https://academic.oup.com/jcem/article/105/7/2262/5805157
Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery
https://academic.oup.com/jcem/article/105/7/2262/5805157
AN ENDOCRINE SOCIETY THEMATIC ISSUE: ADRENAL DISEASE 2020
PUBLISHED BETWEEN 2020, Endocrine Society
An Endocrine Society Thematic Issue: Adrenal Disease 2020
https://academic.oup.com/endocrinesociety/pages/thematic-issue-adrenal-disease-2020
An Endocrine Society Thematic Issue: Adrenal Disease 2020
https://academic.oup.com/endocrinesociety/pages/thematic-issue-adrenal-disease-2020
ENDOCRINOLOGY IN THE TIME OF COVID-19: MANAGEMENT OF ADRENAL INSUFFICIENCY
PUBLISHED APRIL 2020, European Journal of Endocrinology
Endocrinology in the Time of COVID-19: Management of Adrenal Insufficiency
https://eje.bioscientifica.com/view/journals/eje/aop/eje-20-0361/eje-20-0361.xml
Endocrinology in the Time of COVID-19: Management of Adrenal Insufficiency
https://eje.bioscientifica.com/view/journals/eje/aop/eje-20-0361/eje-20-0361.xml
PREVENTION OF ADRENAL CRISIS: CORTISOL RESPONSES TO MAJOR STRESS COMPARED TO STRESS DOSE HYDROCORTISONE DELIVERY
PUBLISHED MARCH 2020, The Journal of Clinical Endocrinology & Metabolism, dgaa133,
Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery
https://academic.oup.com/jcem/article/doi/10.1210/clinem/dgaa133/5805157
Prevention of adrenal crisis: cortisol responses to major stress compared to stress dose hydrocortisone delivery
https://academic.oup.com/jcem/article/doi/10.1210/clinem/dgaa133/5805157
TREATING ADRENAL INSUFFICIENCY: NEW CROSS-SPECIALTY GUIDANCE
ISSUE 135 SPRING 2020, The Endocrinologist, Jeremy Tomlinson and Helen Simpson | Society News
Treating adrenal insufficiency: new cross-specialty guidance
https://www.endocrinology.org/endocrinologist/135-spring20/society-news/treating-adrenal-insufficiency-new-cross-specialty-guidance/
Treating adrenal insufficiency: new cross-specialty guidance
https://www.endocrinology.org/endocrinologist/135-spring20/society-news/treating-adrenal-insufficiency-new-cross-specialty-guidance/
